Interaction of dendrimers with the immune system: An insight into cancer nanotheranostics

The immune system is a network of defense mechanisms, made up organs, tissues, and diversified cells, with the mission detecting attacking invading pathogens. Cancer immunotherapy, which triggers effective anticancer responses via regulation or alteration system, has emerged as one novel powerful strategy to fight cancer in contrast conventional resorts including surgery, radiotherapy, chemotherapy. With recent rapid development nanomedicine, more opportunities are afforded achieve highly efficient immunotherapy. Dendrimers present category nano-sized macromolecules highly-branched three-dimensional structure, favorable biocompatibility, tunable surface functionality. Various kinds functionalized dendrimers dendrimer-based nanohybrids have been explored treatment diagnosis cancer, they recently proven be promising Herein we concisely review interesting immunomodulatory effects dendrimers, particular advances dendrimer-facilitated immunotherapy immunity visualization, clarify possible future perspectives for design immunotheranostics.